basic FUNCTION
| mediating protein-protein interaction within the intron during spliceosome assembly |
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independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing |
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play a role in mRNA export, in particular of histone mRNAs |
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with CUGBP1, SFRS1, act antagonistically to regulate insulin receptor alternative splicing and the relative ratios of SFRS1, SFRS3 to CUGBP1 in different cells determine the degree of exon inclusion |
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SR protein splicing factors, associated with interphase chromatin, and released from hyperphosphorylated mitotic chromosomes, but reassociate with chromatin late in M-phase |
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contribute to the execution of gene-expression programs through their association with distinct endogenous mRNAs |
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SRSF3 and SRSF4 are implicated in histone mRNA metabolism |
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SRSF3 and SRSF4 display unique RNA binding properties underlying diverse cellular regulatory mechanisms, with shared as well as unique coding and non-coding targets |
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nutritional regulation of SRSF3 activity is involved in the differential splicing of the G6PD transcript in response to nutrients |