SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton
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| intracellular,nucleus
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| detected in structures that contain contractile bundles of actin filaments, such as stress fibers and sarcomeres |
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localizes to anchoring structures such as focal adhesions and podosomes, and motile structures such as neuronal growth cones and dorsal ruffles |
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widely expressed protein found in stress fibers, focal adhesions, growth cones, Z-discs, and other actin-based subcellular structures |
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PDLIM1 and palladin were colocalized in the neurites and cell bodies of primary DRG neurons |
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basic FUNCTION
| actin cytoskeleton-associated protein, which is actively involved in the regulation of cell-ECM interaction |
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playing an important role in cell adhesion and motility |
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requiring for the normal organization of the actin cytoskeleton and focal adhesion |
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participating in modulation of actin cytoskeleton by binding to a variety of scaffold and signaling molecules |
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actin-associated protein playing critical roles in establishing cell morphology and maintaining cytoskeletal organization in a wide variety of cell types |
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may playing an important role in recruiting profilin to sites of actin dynamics |
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playing a potential role in generating specialized, actin-based cell morphologies via both direct actin cross-linking activity and indirect scaffolding activity |
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may function as a direct binding partner for F-actin |
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playing an essential role for cell-ECM interaction through maintaining normal actin cytoskeleton architecture and stabilizing beta1-integrin protein |
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participate in modulation of actin cytoskeleton by binding to a variety of scaffold and signaling molecules |
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shares with myotilin the ability to bind directly to F-actin, and to crosslink actin filaments into bundles |
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actin-organizing activity of palladin plays a central role in promoting cell motility |
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essential for expression of the full complement of contractile proteins necessary for optimal force development of smooth muscle cells derived from EBs (embryoid bodies) |
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actin associated protein, plays a significant role in regulating cell adhesion and cell motility |
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plays a key role in the differentiation of smooth muscle cells in the developing vasculature |
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actin-bundling protein that functions to control the actin cytoskeleton, as an AKT1-specific substrate that inhibits breast cancer cell migration |
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modulates the subcellular localization of ILKAP and promotes the ILKAP-induced apoptosis |