motifs/domains
| a N-terminal kinase domain followed by the sequence of citron a Rho/Rac binding protein (CRIK short kinase, SK) |
|
a coiled-coil, a leucine-rich, a zinc finger domains (its functions are mediated by its coiled-coil (CC) domain, and not by its kinase domain) |
|
a pleckstrin homology domain |
|
a putative SH3-binding domains |
|
a number of C-terminal domains that facilitate interactions between components of the contractile ring (anillin, actin, myosin, and RhoA) |
SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
|
text
| localization of KIF14 and citron kinase to the central spindle |
|
CDKN1B and CIT colocalized at the contractile ring and mid-body during telophase and cytokinesis |
|
co-localizes with ASPM at the midbody ring |
|
localizes to the cleavage furrow and midbody of mitotic cells, where it is required for the completion of cytokinesis |
basic FUNCTION
| required in human cell division |
|
cell cycle-dependent protein regulating the G(2)/M transition in hepatocytes |
|
might function as a scaffold protein in spine organization through its ability to bind to Golgi membranes and by affecting actin remodelling |
|
ASPM and CIT are expressed during neurogenesis and play important roles in neuronal progenitor cell division |
|
protein essential to neurogenic cell division in the central nervous system |
|
required for cytokinesis and currently considered a cytokinesis-specific effector of active RHOA |
|
specifically required for abscission in mammalian cells |
|
is a crucial abscission regulator that may promote midbody stability through active RHOA and ANLN |
|
maintains correct RHOA localization at the cleavage site, which is necessary for proper RHOA activity and contractile ring dynamics in cytokinesis |
|
is likely to act at the top of the midbody-formation hierarchy by connecting and regulating a molecular network of contractile ring components and microtubule-associated proteins |
|
roles in cytokinesis, and kinase activity of CIT is required for function in controlling cytokinesis |