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FLASH GENE
Symbol TIAM2 contributors: mct - updated : 19-09-2022
HGNC name TIAM Rac1 associated GEF 2
HGNC id 11806
Location 6q25.2      Physical location : 155.411.422 - 155.578.856
Synonym name
  • SIF and TIAM1-like exchange factor
  • T-cell lymphoma invasion and metastasis 2
  • Synonym symbol(s) STEF, FLJ41865, TIAM-2, KIAA2016
    DNA
    TYPE functioning gene
    STRUCTURE 262.41 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text lacking the EX and PDZ motifs
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 6094 - 1701 - 2018 29844364
  • isoform a
  • 11 splicing 2665 - 626 highly in brain tissue 2018 29844364
  • TIAM2S
  • is involved in HCC pathogenesis, and increased expression of TIAM2S promotes epithelial-to-mesenchymal transition and results in proliferation and invasion in liver cancer cells (PMID: 21469146)
  • TIAM2S is a novel regulator of serotonin level, brain neuroplasticity, and locomotion behavior (PMID: 31908036)
  • 27 - 5976 - 1701 - 2018 29844364
    26 - 6002 - 1701 - 2018 29844364
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum highly
     brainbasal nucleiputamen  
     brainforebraincerebral lobefrontal lobe 
     brainforebraincerebral lobeoccipital lobe 
     brainforebraincerebral lobetemporal lobe 
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • from the N terminus, a pleckstrin homology domain
  • a coiled coil region
  • an EX domain
  • the DHR/PDZ (PSD95/disc large/ZO-1) domain
  • a DBL homology domain (DH) modulating the activity of Rac1
  • RHO-like protein
  • PH domain
  • a TSS domain, necessary for the membrane localization of STEF and Rac1 activation, and binding specifically RAP1A active form
  • conjugated LipoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Tiam2 (85.1pc)
    Homologene
    FAMILY
  • TIAM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    text
  • localizes to the plasma membrane in neurites
  • localises at the nuclear envelope
  • basic FUNCTION
  • involved in neural cell development
  • modulating the balance of Rho GTPase activities in the growth cone and, consequently, to control growth cone behavior
  • guanine nucleotide exchange factor for RAC1, involved in regulating APP processing
  • regulating cell migration by microtubule-mediated focal adhesion disassembly throug hthe activation of RAC1 (Rooney 2010)
  • TIAM2 is a positive regulator and the CDC42(Rac1)-GAP (GTPase-Activating Protein) SYDE1 is a negative regulator of the endothelial barrier function
  • TIAM2 promotes the invasion and migration of lung cancer cell, and TNFRSF11B might be one of the main cytokines contributing to this pro-cancer process
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP1A, MAP1B, PARP1, YWHAE
  • TIAM2-mediated RAC1 activity regulates likely MYH10 activity to promote stabilisation of the perinuclear actin cap
  • GULP1 mediates trogocytosis bi-directionally by dynamic engagement with EphB/ephrinB protein clusters in cooperation with the Rac-specific guanine nucleotide exchange factor TIAM2
  • cell & other
    REGULATION
    activated by a physical interaction between its TSS domain and Rap1
    GTP which mediates Rac1 activation and this active form of Rac regulates the alpha cleavage of APP
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic ductal adenocarcinoma (PDAC), and correlated with patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS