Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TIAM2 | contributors: mct - updated : 19-09-2022 |
HGNC name | TIAM Rac1 associated GEF 2 |
HGNC id | 11806 |
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Location | 6q25.2 Physical location : 155.411.422 - 155.578.856 |
Synonym name | |
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Synonym symbol(s) | STEF, FLJ41865, TIAM-2, KIAA2016 |
DNA |
TYPE | functioning gene |
STRUCTURE | 262.41 kb 26 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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text | lacking the EX and PDZ motifs |
EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | LipoP , PhosphoP |
HOMOLOGY |
interspecies | homolog to murine Tiam2 (85.1pc) |
Homologene |
FAMILY |
CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane | |
intracellular | |
intracellular,cytoplasm,cytosolic | |
intracellular,nuclear envelope | |
text | |
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basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | development |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
activated by | a physical interaction between its TSS domain and Rap1 | |
GTP which mediates Rac1 activation and this active form of Rac regulates the alpha cleavage of APP |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |