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FLASH GENE
Symbol CORO2B contributors: - updated : 31-08-2006
HGNC name coronin, actin binding protein, 2B
HGNC id 2256
Location 15q22-q23      Physical location : 68.871.572 - 69.020.142
Synonym name clipin C
Synonym symbol(s) KIAA0925
DNA
TYPE functioning gene
STRUCTURE 95.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D15S125 - D15S1015 - CORO2B - D15S216 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a WD-40 repeat domain and a succeeding alpha helical region
HOMOLOGY
intraspecies homolog to Dictyostelium discoideum coronin
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • a soluble actin-binding protein
  • accumulating at focal adhesions as well as at neurite tips and stress fibers where it associates with vinculin,suggesting that coronin 2B plays a specific role in cross-binding the actin cytoskeleton and plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein actin-binding,suggesting that coronin 2B plays a specific role in cross-binding the actin cytoskeleton and plasma membrane
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS