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FLASH GENE
Symbol ACSL6 contributors: - updated : 17-09-2004
HGNC name acyl-CoA synthetase long-chain family member 6
HGNC id 16496
Location 5q31      Physical location : 131.289.151 - 131.347.349
Synonym name
  • fatty-acid-Coenzyme A ligase, long-chain 6
  • long chain fatty acid CoA synthetase 2
  • Synonym symbol(s) LACS2, ACS2, LACS5, KIAA0837, FACL6
    EC.number 6.2.1.3
    DNA
    TYPE functioning gene
    STRUCTURE 57.00 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two splicing isoforms-a long,a short
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3130 - 667 - Yagasaki
    - splicing 2560 77.7 697 - Malhotra
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage predominantly in erythrocytes precursors
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, bone marrow, brain hematopoietic system cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    AMP binding enzyme domain
    HOMOLOGY
    interspecies homolog to murine Facl6
    Homologene
    FAMILY
  • ATP-dependent AMP binding enzyme family
  • long-chain fatty-acid-coenzyme A ligase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • playing a role in fatty acid metabolism in brain and the acyl-CoA produced maybe utilized exclusively for the synthesis of the brain lipid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • magnesium Mg2+
  • AMP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS