Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NSA2 contributors: mct - updated : 21-04-2010
HGNC name NSA2 ribosome biogenesis homolog (S. cerevisiae)
HGNC id 30728
Location 5q13.3      Physical location : 74.063.102 - 74.072.734
Synonym name
  • TGF beta-inducible nuclear protein 1
  • hairy-cell leukemia, gene 1
  • Nop seven-associated 2
  • Synonym symbol(s) YR-29, CDK105, HCL-G1, HUSSY-29, TINP1, FLJ94393
    DNA
    TYPE functioning gene
    STRUCTURE 9.63 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map see ENC1
    regionally located located on the telomeric side on the breakpoint
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1104 30 260 - 2010 19932687
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately Homo sapiens
    Lymphoid/Immunethymus   highly Homo sapiens
    Reproductivefemale systemplacenta  highly Homo sapiens
     male systemprostate  moderately Homo sapiens
    Respiratorylung   moderately Homo sapiens
    Urinarykidney   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two nuclear localization signals (NLSs), also overlapped with nucleolar localization signals (NOLSs),implicated in the nucleolar targeting of NSA2
  • HOMOLOGY
    interspecies ortholog to rattus Cdk105
    Homologene
    FAMILY
  • ribosomal protein S8e family
  • CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text located in the nucleolus of cells
    basic FUNCTION
  • being essential for the large ribosomal subunit biogenesis
  • nucleolar protein involved in cell proliferation and cell cycle regulation
  • may act as a cell cycle repressor and plays a role in cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional partner of the putative GTPase GTPBP4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in hairy-cell leukemia
    constitutional     --over  
    promoted cell growth in different cell lines and regulated the G1/S transition in the cell cycle
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS