SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| mitotic |
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not associated with chromatin after prophase I |
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associated with the two centrioles of a centrosome |
basic FUNCTION
| playing roles in sister chromatid cohesion and DNA repair |
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member of the cohesin complex, enabling proper chromosome segregation |
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may be playing a role in spindle pole assembly during mitosis |
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involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM |
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may be absolutely required for the correct completion of the last steps of DNA replication and required to prevent fragile site expression |
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play an important role in the maintenance of chromosomal integrity by preventing the premature separation of the sister chromatids at the onset of anaphase |
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involved in centrosome/basal body-related functions, such as organization of dynamic arrays of microtubules and ciliary formation |
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may play important roles in nucleation or anchoring of microtubules at interphase of the cell cycle and abscission at the final stage of cytokinesis |
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recruited to microtubule-bound RNA export factor 1 (RAE1) at the mitotic spindle pole |
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important component of DNA repair (ATM- and ATR-dependent phosphorylation of SMC1A and SMC3 are critical for DNA damage response) |
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multiunit complex of SMC1A, SMC3 and RAD21, associates with chromatin after mitosis and holds sister chromatids together following DNA replication |
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SMC1A upregulation is involved in the pathogenesis of glioma |
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in the development, participates in tissue-specific enhancer-promoter interactions and interactions that demarcate regions of correlated regulatory output |
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STAG2, RAD21, SMC1A, SMC3 mutations participate in leukemogenesis through the deregulated expression of genes that are involved in myeloid development and differentiation |
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cohesin ring is a protein complex composed of four core subunits: SMC1A, SMC3, RAD21 and STAG1/STAG2 and is involved in chromosome segregation, DNA repair, chromatin organization and transcription regulation |
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NIPBL, SMC1A, SMC3, RAD21, and HDAC8 genes codify for the "cohesin complex" playing a role in chromatid adhesion, DNA repair and gene expression regulation |