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FLASH GENE
Symbol NUDT6 contributors: mct - updated : 09-02-2018
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 6
HGNC id 8053
Location 4q28.1      Physical location : 123.813.804 - 123.844.123
Synonym name
  • antisense basic fibroblast growth factor
  • nucleoside diphosphate-linked moiety X motif 6
  • Synonym symbol(s) GFG, ASFGF2, FGF-AS, FGF2AS, GFG-1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene, antisens
    text antisense transcript of FGF2 (Li)
    STRUCTURE 30.36 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1197 35 316 localized to mitochondria by an N-terminal targeting sequence (MTS) 2001 11266510
    NUDT6a
    5 - 1129 - 147 localized in the cytoplasm and nucleus 2001 11266510
    NUDT6b
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnerve   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Nudt/MuT (Nudix)domai
  • an atypical nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to murine cleaning gene
    Homologene
    FAMILY Nudix family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • potentially regulator of FGF2 expression whose function is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways
  • potential central role for the FGF2/NUDT6 antisense transcript in the ovarian follicle assembly process
  • histone acetylation and additional chromatin modifiers are important in determining the relative levels of FGF2 and NUDT6, supporting a model in which epigenetic remodeling contributes to their relative expression levels
  • FGF2 and NUDT6 in the regulation of cell transformation and cell cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF2 is regulated endogenously by an overlapping antisense gene called Nudix-type motif 6 (NUDT6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS