basic FUNCTION
| zinc finger protein that is essential for normal hematopoiesis |
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activating the enhancer (delta-A element) of the CD3-delta gene |
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key regulator of hematopoiesis, having an essential role in lymphocyte development, and in regulation of B cell receptor signaling |
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functioning in the specification and the maturation of the lymphocyte |
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playing critical functions in the control of lymphohematopoiesis and immune regulation |
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playing a role in the neuroendocrine system, highlighting a critical contribution to the development of the hypothalamic-pituitary somatotrophic axis |
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acting both as an activator and repressor of transcriptionand may act together with other transcription factors to modulate promoter activity |
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carry out critical functions during lymphocyte development |
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required for normal lymphoid development |
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may function as a typical transcription factor and may function more broadly, perhaps in the formation of silent and active chromatin structures |
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regulate the pre-BCR component lambda5 in a stage-specific manner |
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its function is controlled by the CK2 and PPP1CC pathways and a balance between these two signal transduction pathways is essential for normal cellular function and for the prevention of malignant transformation |
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zinc finger protein that is involved in gene regulation and chromatin remodeling |
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in the nucleus, forms complexes with ubiquitin, providing evidence that IKZF1 degradation involves the ubiquitin/proteasome pathway |
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required for the normal development of lymphocytes and other blood cell lineages, and have an important role in haematopoietic malignancies |
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Ikaros family members are critical for a functional immune system that confers protection against invading pathogens, while minimising the risk of leukaemic transformation, immune pathology, and autoimmunity |
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is essential in both the myeloid and lymphoid development |
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IRF5-IKZF1 axis is a critical modulator of IgG2a/c class switching |
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zinc finger-containing DNA-binding protein that plays a pivotal role in immune homeostasis through transcriptional regulation of the earliest stages of lymphocyte ontogeny and differentiation |
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important functional interplay between Ikaros, GATA factors, and the NOTCH signaling pathway in specification and homeostasis of the megakaryocyte lineage |
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in multipotent, hematopoietic progenitors, IKZF1 supports transcriptional priming of genes promoting lymphocyte differentiation |
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novel roles of IKAROS in regulating normal human hematopoietic cells |
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IKZF1 and HDAC1 regulate the epigenetic signature in leukemia, via regulation of KDM5B transcription |
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functions as a guardian of B-1 lymphoid pattern, and its absence directs the differentiation of B-1 cells into phagocytes |
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is a fundamental regulator of Polycomb repressive complex 2 (PRC2) function in developing T cells |
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IKZF1 is required to limit B1 cell homeostasis in the adult |
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IKZF1 and FOXP1 are transcription factors that play key roles in normal lymphopoiesis and lymphoid malignancies |
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is a haematopoietic transcription factor required for mammalian B-cell development |