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FLASH GENE
Symbol PLA2G4B contributors: - updated : 21-09-2005
HGNC name phospholipase A2, group IVB (cytosolic)
HGNC id 9036
Location 15q11.2-q21.3      Physical location : 42.131.010 - 42.140.345
Synonym name phospholipase A2, group IVB , calcium-dependent
Synonym symbol(s) CPLA2B, cPLA2-beta
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Nervousbrainhindbraincerebellum highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains a catalytic sequence containing an histidine motif characteristic of the caspase proteases
HOMOLOGY
intraspecies homolog to PLA2G2A
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • implicated in the initiation of the inflammatory response through its lysophospholipid activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS