basic FUNCTION
| global coactivator for the nuclear receptor family |
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estrogen receptor coactivator playing a role in mammary epithelial cell differentiation and breast carcinogenesis |
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essential role for embryonic fibroblast differentiation pathway (adipogenesis,but not myogenesis) |
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essential for normal development of vital organ systems |
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acting as a coactivator of FXR and underscore the importance of DRIP205 in modulating the bile acid response of NR1H4 target genes |
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catalyzing PTEN polyubiquitination that negatively regulates PTEN stability |
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plays a key role in facilitating ligand-dependent interactions of this multisubunit coactivator complex with nuclear receptors through their ligand binding domains |
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dispensable for the regulation of PTEN stability and localization |
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via interactions with GGA3 and cargo (LAPTM5), regulates cargo trafficking to the lysosome without requiring cargo ubiquitination |
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core Mediator subunits MED1 and MED17 are recruited to the CDKN1A locus |
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general coactivator complex connecting transcription activators and RNA polymerase II |
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mediator subunit regulating peroxisome proliferator-activated receptor gamma-stimulated adipogenesis by alternative mechanisms |
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mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of ADRB2 |
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is capable of binding to SPY1A and the dominant negative forms and knockdown of NEDD4 reduce ubiquitination and further degradation of SPY1A |
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cofactor involved in not only the regulation of nuclear receptors but also the activation of GATA6 transcription |
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required for proper heart development and likely vasculature development as well |
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differentially expressed in mammary epithelial cells and plays a role in luminal lineage determination |
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plays a broad role in nuclear receptor-mediated transcription by anchoring the Mediator complex to diverse promoter-bound nuclear receptors |
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strong suppressive function of MED1 on energy expenditure pathways in muscle |
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may be acting in the muscle to regulate glucose and energy metabolism |
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NEDD4 and ARRB1 as key regulators of SLC9A1 ubiquitylation, endocytosis, and function |
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E3 ubiquitin ligase responsible for GRIA1 ubiquitination, a modification that regulates multiple aspects of GRIA1 molecular biology including trafficking, localization and stability |
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ARGLU1 and MED1 colocalize on the same estrogen receptor target gene promoter upon estrogen induction |
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is a key regulator of FGFR1 endocytosis and signalling during neuronal differentiation and embryonic development |
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functions in the endosomal-lysosomal pathway, and robustly ubiquitinates SNCA, unlike ligases previously implicated in its degradation |
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plays an essential role for the activation of the genetic program involved in the terminal maturation stage of invariant natural killer T-cell development |
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has a critical role in regulating hair/epidermal proliferation and differentiation |
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. has roles in maintaining quiescence of keratinocytes and preventing depletion of the follicular stem cells |
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is a context-dependent GATA1 coregulator, and also exerts specialized functions in erythroid cells to control GATA1-independent, cell-type-specific genes, which include candidate regulators of erythroid cell development and function |
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MED1 stimulated transcription from the TSHB gene promoter in a T3-dependent manner |
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functions as a coactivator of several transcription factors and is implicated in adipogenesis of the lipid and glucose metabolism |
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has an important affect on mitochondrial function |
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expression of multiple subunits of the Mediator complex, including MED1, MED4, or MED14, is frequently dysregulated in different types of cancer |