basic FUNCTION
| acting as a CD2 tail binding protein |
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involved in the control processes for cell adhesion |
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involved in regulation of the actin cytoskeleton |
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may regulate the WAS actin-bundling activity |
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bridging the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation |
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may play a role as a scaffold protein between PTPN12 and WAS and allows PTPN12 to dephosphorylate WAS |
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having the potential to physically couple CD2 and CD2AP to WAS |
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acting downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation |
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down-regulating CD2-stimulated adhesion through the coupling of PTPN12 to CD2 |
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is not an essential regulator of the major types of caspase-1-activating inflammasomes, nor is it a critical regulator of the caspase-1 independent turpentine-induced inflammatory pathway 2) |
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cytoskeletal adaptor and F-BAR protein that has been implicated in autoinflammatory disease, most notably in the PAPA syndrome |
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endogenous PSTPIP1 negatively regulates macrophage podosome organization and matrix degradation |
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novel role for PSTPIP1 and WAS in orchestrating different |
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types of actin-based protrusions |
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adaptor protein associated with the cytoskeleton that is mainly expressed in hematopoietic cells |