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FLASH GENE
Symbol ST13 contributors: mct - updated : 17-03-2010
HGNC name suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
HGNC id 11343
Location 22q13.2      Physical location : 41.220.602 - 41.252.687
Synonym name
  • progesterone receptor-associated p48 protein
  • renal carcinoma antigen NY-REN-33
  • aging-associated protein 2
  • heat shock 70kD protein binding protein
  • Synonym symbol(s) SNC6, HSPABP1, HIP, P48, FAM10A1, AAG2, FAM10A1, FAM10A4, FLJ27260, HOP, HSPABP, MGC129952, PRO0786, HOP
    DNA
    TYPE functioning gene
    STRUCTURE 32.09 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D22S272 - PDGFB - NAGA NAGA - ST13 - D22S423 - D22S1171 - D22S274 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3214 41.3 369 - 1998 9452498
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • FAM10 family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • characterized by its ability to bind the two chaperones, HSP70 and HSP90
  • provides a physical link between HSP70 and HSP90 and modulates the activities of both of these chaperone proteins
  • displays broad anti-aggregation functions and has a critical function in preventing protein misfolding pathologies
  • functional role, in preventing the co-aggregation of HSP70 with SNCA, thereby reducing the toxicity of amyloidogenesis
  • substrate of GRK5 in cells, and phosphorylation of ST13 by GRK5 plays a role in modulating CXCR4 internalization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cofactor of heat shock protein 70 (Hsp70)
  • GRK5 bound to and phosphorylated ST13 on Ser-346 in cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    mostly expressed in colorectal epithelia and adenocarcinoma cells
    constitutional     --low  
    decreased expression could facilitate depletion of Hsp70 by amyloidogenic polypeptides, impairing chaperone proteostasis and stimulating neurodegeneration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    overexpressed ST13 as mediated by oncolytic adenovirus could exert potent antitumor activity via the intrinsic apoptotic pathway and has the potential to become a novel therapeutic for colorectal cancer gene therapy
    ANIMAL & CELL MODELS