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FLASH GENE
Symbol EEF1E1 contributors: mct/npt - updated : 08/12/2008
HGNC name eukaryotic translation elongation factor 1 epsilon 1
HGNC id 3212
Location 6p24.3      Physical location : 8.073.594 - 8.102.828
Synonym name
  • homolog of rat elongation factor
  • multisynthetase complex auxiliary component p18
  • ARS-interacting multifunctional protein 3
  • elongation factor p18
  • aminoacyl-tRNA synthetase-interacting multifunctional protein-3
  • Synonym symbol(s) P18, AIMP3
    DNA
    TYPE functioning gene
    STRUCTURE 23.14 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D6S1640 - D6S1547 - D6S1674 - EEF1E1 - D6S470 - D6S410 - D6S259 - D6S1559 - D6S260 - D6S288 - D6S422 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1103 19 174 - Kim (2008)
    - - 609 15.4 139 - Kim (2008)
  • including an alternate 3' terminal exon compared to variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestivesalivary gland   highly
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systembreastmammary gland moderately
     male systemtestis   
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connective   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GST C-terminal domain
  • conjugated Other
    HOMOLOGY
    interspecies homolog to rattus Eef1e1 (87.9 pc)
    homolog to murine Eef1e1 (88.5 pc)
    Homologene
    FAMILY
  • glutathione S-transferase family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • cytoplasmic under growth arrest conditions
  • translocated into the nucleus when growth resumes (S phase) and following DNA damage
  • basic FUNCTION
  • acting as a positive modulator of ATM response to DNA damage
  • acting as a negative regulation of cell proliferation
  • involved in the positive regulation of DNA damage response, signal transduction by p53 class mediator
  • playing a role in the positive regulation of apoptosis
  • acting as a tumor-suppressor through the interaction with ATM
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • NABP2 and EEF1E1, might be involved in BRCA1-pathway
  • a component
  • component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATM and ATR
  • is released from MARS by UV irradiation-induced stress
  • cell & other
    REGULATION
    induced by DNA damaging agents, such as UV, adriamycin, actinomycin D and cisplatin
    Other acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    down-regulated in various cancer tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS