basic FUNCTION
| translocating nuclear-encoded proteins into the mitochondrion |
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mediates translocation of preproteins across and their insertion into the mitochondrial inner membrane (Popov-Celeketi& |
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263; 2008) |
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key component of the mitochondrial import machinery (Ahting 2009) |
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TIMM23 complex translocates and inserts proteins into the mitochondrial inner membrane (Tamuar 2009) |
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seems to require the TIMM8A-TIMM13 complex for translocation across the outer membrane (Hasson 2010) |
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molecular link between the TIMM23 transport machinery and assembly of respiratory-chain complexes that regulate mitochondrial protein synthesis in response to their assembly state (PMID |
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central role of the intermembrane space domain of TIMM23 in the formation and regulation of the presequence translocase |
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majority of inner membrane protein precursors are synthesized in the cytosol, but precursors with a cleavable presequence are imported by the presequence translocase (TIMM23 complex), while other precursors containing internal targeting signals are imported by the carrier translocase (TIMM22 complex) |
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TIMM22, TIMM23 import pathways depend on the presence of a membrane potential, which is generated by the activity of the respiratory chain |
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is a key component of the mitochondrial import machinery, mediating preprotein translocation across the mitochondrial inner membrane |