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FLASH GENE
Symbol LDOC1 contributors: mct - updated : 05-12-2011
HGNC name leucine zipper, down-regulated in cancer 1
HGNC id 6548
Location Xq27.2      Physical location : 140.269.939 - 140.271.310
Synonym name breast cancer, up-regulated 1
Synonym symbol(s) BCUR1, Mar7, Mart7
DNA
TYPE functioning gene
STRUCTURE 1.38 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1388 17 146 - 2011 21310924
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   lowly
Endocrinethyroid   highly
Nervousbrain   highly
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines breast cancer cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta lowly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • leucine zipper-like motif at the N terminal
  • a proline-rich region (marked similarity to a SH3 binding domain)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a possible role in transcriptional regulation
  • product may have an important role in the development and/or progression of some cancers
  • regulator of the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB)
  • may play a role in normal B-cell development
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text negative control of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with MZF1 (enhancing the activity of LDOC1 for inducing apoptosis)
  • binds directly to the verprolin homology domain of WASF3
  • cell & other
    REGULATION
    inhibited by negatively regulated by WASF3
    Other down-regulated in some cancer cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in some cancer cell lines(in pancreatic cancer)
    constitutional     --over  
    caused externalization of the cell membrane phosphatidylserine, which was characteristic for early-phase apoptotic events, and reduced cell viability in some human cell lines
    tumoral     --low  
    dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LDOC1 mRNA expression is an excellent predictor of overall survival in untreated chronic lymphocytic leukemia patients
  • Therapy target
    ANIMAL & CELL MODELS