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FLASH GENE
Symbol PLCL2 contributors: mct - updated : 15-01-2018
HGNC name phospholipase C-like 2
HGNC id 9064
Location 3p24.3      Physical location : 16.926.451 - 17.132.097
Synonym name
  • rat inositol 1-4-5 triphosphate binding protein mouse
  • phospholipase C, epsilon 2
  • Synonym symbol(s) KIAA1092, PLCE2, FLJ13484
    DNA
    TYPE functioning gene
    STRUCTURE 287.92 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3964 - 1001 - 1999 10581172
    - - 4170 - 1127 - 1999 10581172
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivefemale systemplacenta  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C2 domain
  • an EF-hand domain
  • a PI-PLC X-box domain
  • a PI-PLC Y-box domain
  • HOMOLOGY
    interspecies homolog to murine Plcl2,phospholipase C-like 2
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in signal transduction pathways
  • PLCL1, PLCL2, are likely positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS