Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PFKFB4 contributors: - updated : 19-09-2007
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
HGNC id 8875
Location 3p22-p21      Physical location : 48.555.125 - 48.594.227
Synonym name
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4
  • bifunctional enzyme with kinase and biphosphatase activities
  • EC.number 2.7.1.105
    DNA
    TYPE functioning gene
    STRUCTURE 39.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3503 - 469 - Minchenko
    - - 1733 - 435 - Minchenko
    - - 1724 - 278 - Minchenko
    - - 1491 - 434 - Minchenko
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • responsible for the synthesis and breakdown of fructose 2,6 biphosphate
  • key metabolite in the regulation of glycolysis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS