protein
| interacting with MAP3K1 (MAP3K1 and STK10 may have opposing roles in regulating the CD28RE/AP1 element of IL2) |
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in epithelial cells, ezrin is mainly phosphorylated at T567 by STK10 |
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STK10 and SLK are functionally the major relevant kinases involved in the steady-state phosphorylation of EZR in Jeg-3 cells |
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involved in lymphocyte migration and polarization and can phosphorylate EZR, RDX, and MSN (the ERM proteins) |
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cleavage of STK10 during apoptosis abolishes its kinase activity, causing a decrease in ERM phosphorylation, crucial to the role of the ERM proteins in linking the plasma membrane to actin filaments |
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EZR through STK10 is only phosphorylated at the plasma membrane, and with high specificity by the apically localized kinase STK10 |
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MISP directly interacts with EZR and STK10-activated EZR ensures appropriate cortical MISP levels in mitosis by competing with MISP for actin-binding sites at the cell cortex |