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FLASH GENE
Symbol WDR3 contributors: npt/ - updated : 28-11-2002
HGNC name WD repeat domain 3
HGNC id 12755
Location 1p13-p12      Physical location : 118.472.371 - 118.503.049
Synonym name dJ776P7.2 (WD repeat domain 3)
Synonym symbol(s) FLJ12796
DNA
TYPE functioning gene
STRUCTURE 30.66 kb     27 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 3877 106 943 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
Nervouscentral   
cell lineage hematopoietic cell lines
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten WD-40 repeats
  • a nuclear localization signal (NLS) between WD4 and WD5
  • a C terminal second NLS
  • a potential tyrosine kinase phosphorylation site
  • a cAMP-and cGMP dependent protein kinase phosphorylation site
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae dip2
    Homologene
    FAMILY
  • WD repeat WDR3/UTP12 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in apoptosis, gene regulation, cell cycle progression
  • CELLULAR PROCESS cell cycle, progression
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS