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FLASH GENE
Symbol LRRFIP1 contributors: mct - updated : 20-06-2012
HGNC name leucine rich repeat (in FLII) interacting protein 1
HGNC id 6702
Location 2q37.3      Physical location : 238.536.223 - 238.690.288
Synonym name
  • GC-binding factor 2
  • transcription factor 9-like
  • Synonym symbol(s) TRIP, GCF2, FLAP1, HUFI-1, FLIIAP1, FLAP-1, GCF-2
    DNA
    TYPE functioning gene
    STRUCTURE 154.07 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text specific alternatively spliced transcripts 3.9 and 2.8kb expressed in heart and skeletal muscle (Fong)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 4109 - 640 - 1999 10366446
    12 - 3599 - 394 - 1999 10366446
    11 - 4510 - 808 - 1999 10366446
    10 - 4438 86.4 784 - 1999 10366446
    8 - 4342 - 752 - 1999 10366446
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   moderately
    Reproductivemale systemtestis  moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticplatelet Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text heart highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    coiled motifs that interact with the LRR domain of FLI
    HOMOLOGY
    interspecies homolog to murine Lrrfip1
    homolog to Drosophila CG8507
    intraspecies homolog to TAR RNA interacting protein
    Homologene
    FAMILY
    CATEGORY regulatory , RNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • providing a link between RNA and the actin cytoskeleton
  • transcriptional repressor overexpressed in cancer cell lines with a role in regulating expression of the EGFR
  • being the first TNF-alpha repressor identified
  • recruited to RNA-containing vesicles and potentilly participates in cell responses to virus at early time points, being important for type I IFN induction
  • functions as a component of the platelet cytoskeleton, where it interacts with the actin-remodeling proteins Flightless-1 and Drebrin
  • regulator of toll-like receptor (TLR) pathway signaling
  • potentially phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures
  • plays potentially an important role in colorectal cancer metastasis by regulating RHOA-induced cell adhesion, migration, and invasion
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to double-stranded GC-rich RNA
    small molecule
    protein
  • binding to FLI (leucine-rich repeat)
  • interacted directly with CTNNB1, GRIP1 and EP300 and enhanced their activity
  • MYD88 interacting with LRRFIP2 and LRRFIP1, and both are positive regulators of NF-kappaB activity
  • interacted with beta-catenin and promoted the activation of beta-catenin, which increased IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3
  • cell & other
    REGULATION
    induced by phorbol esters
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to abdominal adiposity
    Variant & Polymorphism SNP rs11680012 was associated with abdominal adiposity (
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS