basic FUNCTION
| may be playing a role in postsynaptic function |
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can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I |
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putative specific role of APLP1 in cell adhesion (Kaden 2009) |
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a key modulator of the cellular stress response, inducing cell-cycle arrest, apoptosis, senescence and cell differentiation (Tang 2007) |
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TP53-dependent induction of APLP1 is involved in neural cell death, and which may exacerbate neuronal cell loss in some acute or chronic neurodegenerative disorders (Tang 2007) |