motifs/domains
| three N terminal (RD) repression domains with a SIAH2 and a putative SIN3 interacting motifs |
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third NR-interaction domains ID (ID3) upstream of two IDs (ID1 and ID2) and its core motif (IDVII), rather than an extended helical motif, is known to be involved directly in the exclusive interaction of ID3 with the thyroid hormone receptor (TR) |
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a deacetylase activation domain (DAD), conserved in the highly related NCOR2, for association with HDAC3 |
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a domain homolog to a repeat identified in yeast SWI3, GTF3B and a second putative repression domain in the C terminal region |
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two C terminal interaction domains containing a conserved sequence referred to as the NCOR box |
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two SANT domains |
basic FUNCTION
| recruiting the CoR/Sin3/HDAC1/HDAC2 complex, resulting in chromatin remodeling and repression of transcription |
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inhibiting transcription by hormone receptors in absence of ligand |
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promoting chromatin condensation |
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functions as an activating subunit for the chromatin modifying enzyme histone deacetylase 3 (HDAC3) |
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participates in DACH1 repression of TNFSF11 gene expression in marrow stromal/preosteoblast cells |
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central role to control the actions of many transcriptional factors, in large part, by recruitment and activation of a range of chromatin remodeling enzymes |
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plays an adaptive role in muscle physiology and that interference with NCOR1 action could be used to improve muscle function |
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key physiological regulator of muscle mass and function |
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negative regulator of both muscle mass and mitochondrial oxidative metabolism |
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NCOR1 and NCOR2 are coregulators of nuclear receptor (NR) action |
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is the principal mediator of thyroid hormone (TH) sensitivity |
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NCOR1 and NCOR2 collaborate to control hepatic lipid content, which likely reflects their cooperative activity in regulating the action of multiple NRs including the TH receptor (TR) |
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NCOR1 acquires the ability to repress active PPARG-mediated transcription via G-protein pathway suppressor 2 (GPS2), a component of the NCOR corepressor complex 2) |