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FLASH GENE

Symbol

IL16

contributors: mct/ - updated : 21-06-2006

HGNC name	interleukin 16 (lymphocyte chemoattractant factor)
HGNC id	5980

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q25.1      Physical location : 81.489.218 - 81.605.103
Synonym name	lymphocyte chemoattractant factor
	neuronal interleukin 16
	prointerleukin 16
Synonym symbol(s)	LCF, IL-16, prIL-16, HsT19289, FLJ16806, FLJ42735, FLJ44234

DNA

TYPE	functioning gene
STRUCTURE	115.90 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box)
	Binding site   transcription factor
text structure	two promoter elements (one constitutive and another inducible) both promoters contain two CAAT box like motifs and three binding sites of GA-binding portein (GA BP) transcription factors

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004513 7 - 6077 NP_004504 66.5 631 - - NM_172217 18 - 8065 NP_757366 141.6 1332 - - NM_001172128 19 - 8322 NP_001165599 - 1331 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune activated B lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two PDZ/DHR domains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies	homolog to murine Il16
	homolog to C.elegans F59a3.8

Homologene

FAMILY

CATEGORY

immunity/defense , signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	inducing the chemotactic and immunomodulatory responses of CD4+lymphocytes
	monocyte, eosinophil and lymphocyte chemoattractant factor
	modulating T-cell activation and replication of HIV
	inducing T-lymphocyte expression of interleukine two receptor
	involvement of the IL16 precursor molecules in myosin-based contractile processes, most likely in cell motility

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	anti-pathogen response

PATHWAY

metabolism

signaling

cell to cell signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

CD4 receptor

cell & other

REGULATION

induced by

GABP alpha and beta

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS