basic FUNCTION
| playing a role in generating asymetric cell division during neurogenesis |
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in enabling neural progenitor cells to balance self-renewal and neuron production by segregating asymmetrically to the progenitor daughter cells to specify their fates |
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NUMB signaling seems to play two contradictory roles: namely, it promotes progenitor over neuronal fates but is also required for neuronal differentiation |
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playing a crucial role in the maintenance of radial glia adherens junctions and, consequently, the integrity of the neurogenic epithelium |
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required for the tissue architecture of neurogenic niches and the cerebral cortex |
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controlling TP53 tumour suppressor activity by preventing ubiquitination and degradation of TP53 |
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major determinant of binary cell fates and required for the differentiation of cerebellar granule cell progenitors (GCPs) at a stage of development responsive to the morphogenic glycoprotein Hedehog |
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endocytic protein that is proposed to influence clathrin-coated pit assembly |
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mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast |
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endocytic receptor for P-selectin that may be responsible for the rapid internalization of P-selectin when endothelial activation ends |
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depletes chronic myelogenious leukemia stem cells |
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regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling |
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sensor of HGF signalling or Src activity during epithelial-mesenchymal transition |
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NUMB phosphorylation may act as an important regulatory process in the NOTCH1 pathway |
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important cell fate determinant that is asymmetrically inherited during mitosis and controls the fate of sibling cells by inhibiting the Notch signaling pathway in neural tissue |
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modulates intestinal epithelial cells towards the goblet cell phenotype by inhibiting the Notch signaling pathway |
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NUMB and NUMBL have evolved to acquire at least partially distinct functions |
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regulates steady-state levels of TP53 in cells by disrupting TP53-MDM2 acidic domain interactions |
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is an endocytic adaptor protein that regulates the endocytosis and trafficking of transmembrane receptors including NOTCH1, CDH1, and integrins |
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RBFOX3-dependent NUMB alternative splicing plays an important role in the progression of neuronal differentiation during vertebrate development |
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NUMB inhibits NOTCH1 signaling by promoting the degradation of the NOTCH1 intracellular domain in cardiomyocytes |
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novel role of NUMB that lies at the heart of TCR signaling initiation and termination |
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importance of NUMB and NUMBL in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis |