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FLASH GENE
Symbol SLC7A8 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
HGNC id 11066
Location 14q11.2      Physical location : 23.594.505 - 23.652.849
Synonym name
  • integral membrane protein E16H
  • L-type amino acid transporter 2
  • integral membrane protein E16H
  • large neutral amino acids transporter small subunit 2
  • Synonym symbol(s) LAT2, LPI-PC1
    DNA
    TYPE functioning gene
    STRUCTURE 58.35 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D4S72 - D4S550 - D4S283 - TRA@ - DAD1 - SLC7A7 - SLC7A8 - D4S990 - MYH7 - qter
    Authors Bassi (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4237 - 535 - Park (2005)
    9 - 3145 - 332 - Park (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • two conserved cysteine residues between TM3 and TM4, the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • amino acid-polyamine-organocation (APC) superfamily
  • L-type amino acid transporter (LAT) family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • coexist with SLC16A10 in the basolateral membrane of the renal proximal tubules (Park 2005)
  • expressed in various tissues, including the intestinal wall, blood-brain barrier, and kidney (Del Amo 2008)
  • basic FUNCTION
  • involved in epithelial aminoacid (re)absorption, broad scope neutral aminoacids transporter
  • contribute to the renal reabsorption of neutral amino acids in the basolateral domain of epithelial proximal tubule cells (Park 2005)
  • play essential roles in the reabsorption of neutral amino acids from the epithelial cells to the blood stream in the kidney (Park 2005)
  • with SLC7A5, functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids (Omidi 2008)
  • may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism (Capelo 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein 4F2hc/CD98 at the basolateral membrane to form a complex mediating y+L-type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
  • system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS