basic FUNCTION
| multidomain guanine nucleotide exchange factor (promoting the exchange of GDP by GTP) |
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may be functioning in vesicle trafficking |
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may be playing a role in axonal development and mature brain |
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playing a necessary role for maintenance of hippocampal pyramidal neuron dendrites and dendritic spines |
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playing a critical role in nerve growth factor signaling through NTRK1 |
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controls activity-dependent structural and functional plasticity of dendritic spines |
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plays a critical role in axon extension and maintenance of dendritic spines |
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multifunctional Rho GDP/GTP exchange factor, playing a vital role in cytoskeletal organization, affecting process initiation and outgrowth in neurons |
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key regulator of spine morphogenesis |
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may represent a common risk factor for vascular diseases |
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Rho guanine nucleotide exchange factor localized to the postsynaptic density (PSD), and modulating dendritic spine morphology |
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is an essential and selective modulator of NMDA receptor-dependent synaptic plasticity in the hippocampus |
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role in secretory granule function and having an expression outside of the nervous system |
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functions as a guanine nucleotide exchange factor for RAC1 in smooth muscle cells (SMCs), and promotes SMC migration and proliferation |
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GTP-exchange factor protein playing a role in cytoskeletal remodeling and dendritic spine formation in neurons |
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may play a role in paracrine and/or endocrine signaling events that control skeletal bone remodeling and the maintenance of bone mass |
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is critical for spine morphogenesis on cortical pyramidal neurons |