basic FUNCTION
| likely involved in follicular development and oocyte maturation modulating selectively FSH function |
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could play a physiological role in the monotropic rise of FSH secretion by the pituitary during the estrous and menstrual cycle and in the negative regulation of FSH receptor in the ovary, plaiyng a major role in female fertility |
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oocyte-secreted factor critical for the regulation of ovarian physiology (Saito 2008) |
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ovarian follicle organizer whose adequate function is critical for female fertility (Rossetti 2009) |
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having a necessary and sufficient role for the specification of dorso-anterior structures (Di Pasquale 2009) |
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GDF9 and BMP15 are likely germ cell-specific factors in the testis, and GDF9 can modulate key Sertoli cell functions |
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play likely roles in corpus luteum activity |
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crucial role of GDF9 and BMP15 in female fertility |
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BMP15 and GDF9 promoted activation of human primordial follicles from girls/women in a dose-dependent manner, but GDF9 seems more beneficial |
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GDF9 and bone morphogenetic protein 15 (BMP15) are two proteins selectively expressed in the oocyte which are essential for normal fertility |
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GDF9 and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production |
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GDF9 and BMP15 act synergistically to stimulate granulosa cell proliferation, a response that also involves species-specific non-SMAD signalling pathways |