basic FUNCTION
| mediating the signal transduction leading to the activation of NF-kappaB (regulation of gene expression) |
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acting as a positive regulator of apoptosis and a negative regulation of cell proliferation |
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limiting the proliferative potential of autoreactive CD8 effector T cells |
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important in cell development, and proliferation, and also pathway-related to terminal differentiation in many fetal tissues and organs |
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protecting the body against autoimmunity |
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receptor for TNFSF8/CD30L |
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regulator of T(h)2 responses in the effector-memory phase and a regulator of IL13 production in memory cells in the lung |
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its expression is associated with superficial cutaneous fungal infections |
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playing a role in the regulation of cellular growth and transformation of activated lymphoblasts |
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important role of both TNFRSF4 and TNFRSF8 during CD8(+) T-cell activation, and long-term CD8 persistence after contraction is regulated not only by stimulatory receptors but also by the nature of the antigen or how the antigen is presented |
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inducible NK-cell receptor critical for innate immunity against cytomegalovirus ( |