Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DIRAS3 contributors: mct - updated : 02-10-2013
HGNC name DIRAS family, GTP-binding RAS-like 3
HGNC id 687
Location 1p31.3      Physical location : 68.511.646 - 68.516.460
Synonym name
  • RAS-related GTP-binding protein member 1
  • ras homolog gene family, member I
  • Synonym symbol(s) NOEY2, RHOI, ARHI
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text
  • located within an intron of a lncRNA called GNG12-AS1
  • STRUCTURE 5.67 kb     2 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure CpG islands I and II are located in the promoter region, whereas CpG island III is located in the coding region
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1642 26 229 - 2013 23357870
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas   highly Homo sapiens
    Nervousbrain    
    Reproductivefemale systemovary  highly Homo sapiens
     male systemtestis  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING maternally
    text
  • maternally imprinted growth regulatory
  • normally expressed only from the paternal allele, and the maternal allele is silenced and has a differentially methylated promoter (DMR2) and an upstream CpG island containing a CTCF binding site (DMR1)
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • small G protein, containing three motifs typical of the Ras/Rap family members,i.e.
  • a highly conserved GTP binding domain
  • a putative effector domain
  • the membrane localization CAAX motif
  • HOMOLOGY
    intraspecies homolog to RAP2A
    Homologene
    FAMILY Ras/Rap oncogene superfamily member
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers and whose reactivation is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation
  • plays a particularly important role in ovarian cancer cell migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interact with STAT3, and changes in DIRAS3 expression might therefore affect transcription of STAT3 target genes
  • interacts with RAF1 to specifically suppress the activating phosphorylations on MEK and ERK, thus restricting migration of non-cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOI    
    epigenetically silenced in cancer cell lines
    tumoral     --low  
    in breast cancer
    tumoral     --low  
    in > 60p100 of ovarian cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS