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FLASH GENE
Symbol SH2B2 contributors: - updated : 28-12-2006
HGNC name SH2B adaptor protein 2
HGNC id 17381
Location 7q22      Physical location : 101.928.404 - 101.962.177
Synonym name
  • adaptor with PH and SH2 domains
  • adaptor protein with pleckstrin homology and src domains
  • Synonym symbol(s) ADPSD, APS
    DNA
    TYPE functioning gene
    STRUCTURE 33.00 kb     7 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    IMPRINTING paternally
    text expressed both maternally and zygotically
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a pleckstrin homology (PH) domain
  • a Src homology 2 (SH2) domain
  • a tyrosine phosphorylation site
  • HOMOLOGY
    interspecies homolog to rattus Aps
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • adaptor with PH and SH2 domains, phosphorylated upon B-cell receptor stimulation
  • recruited to the autophosphorylated kinase domain of the insulin receptor and initiates the phosphatidylinositol 3-kinase (PI3K)-independent pathway of insulin-stimulated glucose
  • playing a novel negative regulatory roles in BCR signaling, actin reorganization pathways, and control of compartment sizes of B-lineage cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and increasing its activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS