basic FUNCTION
| mediating cellular uptake of transferrin-bound iron in a non-iron dependent manner |
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is a modulator of hepcidin production in response to iron |
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have dual roles in iron metabolism, one is signalling, the other is iron transport |
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mediates transferrin-bound iron uptake by receptor-mediated endocytosis |
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TFR2/HFE complex is required for transcriptional regulation of hepcidin by holo-TF |
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both HFE and TFR2 are necessary for regulation of hepcidin (HAMP) expression |
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TFR2 and HFE are involved in holotransferrin-dependent signaling for the regulation of FURIN which involved Erk phosphorylation |
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may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation |
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involved in iron metabolism by regulating hepcidin production in liver cells |
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EPO and TFR2 are involved in production of GDF15 by erythroid cells |
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exhibits a non hepatic function as a component of the EPOR complex and is required for efficient erythropoiesis |