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FLASH GENE
Symbol HAT1 contributors: npt - updated : 11-02-2002
HGNC name histone acetyltransferase 1
HGNC id 4821
Location 2q31.2-q33.1      Physical location : 172.778.934 - 172.848.599
Synonym name
  • histone acetyltransferase type B catalytic subunit
  • weakly similar to M03C11.4 [C.elegans]
  • Synonym symbol(s) KAT1
    EC.number 2.3.1.48
    DNA
    TYPE functioning gene
    STRUCTURE 69.64 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1672 - 334 - -
    - - 1596 49.51 419 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestiveliver   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • bipartite nuclear localization signal (NLS)
  • secondary structure HAT1 and P46/HAT2 subunits
    HOMOLOGY
    interspecies homolog to Drosophila CG2051
    Homologene
    FAMILY
  • HAT1 family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • histone actyltransferase 1, catalytic subunit, acetylating soluble (not nucleosomal) newly synthesized histone H4 at Lys5 and Lys12,and H2A at Lys5
  • likely involved in generating modified H4 required for replication-dependent chromatin remodelingand required for DNA repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS