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Symbol DDX5 contributors: mct - updated : 19-10-2015
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
HGNC id 2746
Location 17q24.1      Physical location : 62.494.373 - 62.502.484
Synonym name
  • nuclear antigen 68kD
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kDa)
  • probable ATP-dependent RNA helicase DDX5
  • DEAD box-5
  • helicase, RNA, nuclear 1
  • RNA-dependent ATPase
  • Synonym symbol(s) G17P1, HELR, HLR1, P68, HUMP68, DKFZp434E109, DKFZp686J01190
    EC.number 3.6.1.-
    TYPE functioning gene
    STRUCTURE 8.11 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box) (TATA box)
    Binding site   transcription factor
    text structure binding sites for Sp1, AP-2, CRE, MYC
    MAPPING cloned Y linked N status provisional
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3769 - 614 - 1990 2349099
    Type ubiquitous
       expressed in (based on citations)
    SystemCellPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
  • one helicase ATP-binding domain
  • one helicase C-terminal domain
  • conjugated PhosphoP
    mono polymer heteromer , dimer
    interspecies homolog to murine Ddx5 (99.2pc)
    homolog to rattus Ddx5 (99.3pc)
  • DEAD box helicase family
  • DDX5/DBP2 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
  • can localize to the nuclear matrix during interphase by binding AKAP95
  • basic FUNCTION
  • RNA helicase with RNA dependent ATPase activity
  • involved in translation initiation, nuclear and mitochondrial splicing and ribosome and spliceosome assembly
  • important transcriptional regulator, functioning as a coactivator or corepressor, depending on the context of the promoter and the transcriptional complex
  • may act as a tumor cosuppressor in governing p53 transcriptional activity
  • proliferation-associated nuclear antigen, reacting with the simian virus 40 tumor antigen
  • playing a critical role with DDX17 in promoting the assembly of proteins required for formation of the transcription initiation complex and chromatin remodeling
  • coactivator of MYOD1
  • may be involved in pre-mRNA splicing
  • may also confer apoptosis resistance by upregulation of X-chromosome-linked inhibitor apoptosis protein-associated factor 1
  • phosphorylated DDX5 protects cells from programmed cell death by preventing procaspase-8 from proteolytic cleavage
  • androgen receptor transcriptional coactivator
  • involved in multiple myeloma tumorigenesis
  • DDX5 and DDX17 have been shown to act as transcriptional co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ESR1)
  • crucial role for DDX17 in ESR1 co-activation and oestrogen-dependent cell growth and likely distinct but important roles for both DDX5 and DDX17 in regulating ESR1 activity in breast cancer
  • repressor of fibrogenic genes in hepatic stellate cells through interaction with transcriptional complexes
  • is a key TP53-independent target of the CDKN2A and is a novel non-oncogene participant in ribosome biogenesis
  • DDX5 and DDX17 have a dual role in the control of the pro-migratory NFAT5 transcription factor
  • DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation
  • RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    a component
  • identified in the spliceosome C complex
  • DDX5/SRA1 stabilizes the interaction of cohesin with CTCF by binding to both, and is required for proper insulator function
  • binding
  • small molecule nucleotide,
  • ATP binding
  • protein
  • substrate of TLK1 (phosphorylates immunoprecipitated DDX5)
  • phosphorylated DDX5 interacts with nuclear beta catenin and is thus involved in cell proliferation
  • interacting with fibrillarin in nascent nucleoli during late telophase
  • interacting with SARS coronavirus helicase
  • CDKN2A inhibited the interaction between DDX5 and nucleophosmin (NPM), preventing association of DDX5 with the rDNA promoter and nuclear pre-ribosomes
  • DDX5 and DDX17 act are transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration
  • ATP-dependent DEAD-box RNA helicase, is a component of the MAML1 protein complex
  • DDX5 interacts with MAML1 and is associated with the endogenous NOTCH1 transcription activation complex in human T-ALL leukemic cells
  • ARVCF interacts with different proteins involved in mRNA-processing: SRSF1 (SF2/ASF), DDX5, and HNRNPH2
  • cell & other
    Other sumoylation on lys53 modulates its transcriptional activity and promotes its interaction with HDAC1
    PDGF-dependent phosphorylation by c-Abl kinase in the nyucleus
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    increased expression and polyubiquitylated in colorectal tumors, may contribute to colon cancer formation by directly upregulating proto-oncogenes
    tumoral     --over  
    overexpressed in prostate cancer with a possible role in progression to hormone refractory disease
    tumoral fusion      
    gene fused in frame with ETV4 in prostate cancer, leading to the expression of a DDX5-ETV4 fusion protein
    Variant & Polymorphism SNP
  • SNP S480A is linked to a reduced repressive function of DDX5 and thus an enhanced fibrogenic activity
  • DDX5 minor allele is associated with increased risk of developing advanced fibrosis in patients with chronic hepatitis C
  • Candidate gene
    Therapy target
    potential new target for modulating the Notch signaling in leukemia