Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TNFRSF11B | contributors: mct/npt/shn - updated : 19-09-2015 |
HGNC name | tumor necrosis factor receptor superfamily, member 11b |
HGNC id | 11909 |
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Corresponding disease |
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Location | 8q24.12 Physical location : 119.935.796 - 119.964.383 | ||
Synonym name | |||
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Synonym symbol(s) | OPG, OCIF, TR1, FDCR1, MGC29565 |
DNA |
TYPE | functioning gene |
STRUCTURE | 28.59 kb 5 Exon(s) |
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10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter | |||
Binding site | ||||
motif
text structure
| two binding sites for HOXC8 (mediating OPG activation in response to BMP stimulation) |
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MAPPING | cloned | Y | linked | N | status | confirmed |
Map | see COLEC10 |
regionally located | cen - D8S1016 - D8S522 - TNFRSF11B - D8S1823 - D8S269 - qter |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
tissue |
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cells |
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cell lineage | lymphoid cells |
cell lines
fluid/secretion
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at STAGE |
physiological period | fetal |
Text | kidney, liver, lung |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | GlycoP |
mono polymer | homomer , dimer , trimer |
HOMOLOGY |
interspecies | ortholog to Tnfrsf11b, mus musculus |
ortholog to Tnfrsf11b, Rattus norvegicus | |
ortholog to TNFRSF11B, Pan troglodytes |
Homologene |
FAMILY |
CATEGORY | signaling cytokine , receptor |
SUBCELLULAR LOCALIZATION | extracellular |
| plasma membrane |
text | localized to the Weibel-Palade bodies of vascular endothelial cells ![]() |
basic FUNCTION | |
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CELLULAR PROCESS
| cell life, antiapoptosis |
PHYSIOLOGICAL PROCESS | development |
text | skeletal development |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | ![]() |
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cell & other |
REGULATION |
activated by | upregulated by CD40 (TNFRSF5) stimulation |
ASSOCIATED DISORDERS |
corresponding disease(s) | PDB7 |
Other morbid association(s) |
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Susceptibility |
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Variant & Polymorphism SNP , other | |
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Candidate gene
Marker
| ![]() Therapy target
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ANIMAL & CELL MODELS |
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