basic FUNCTION
| regulation of cancer metastasis in malignant melanomas |
|
regulating events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization |
|
directly stimulating gonadotrophin-releasing hormone release via KISS1R, and as a relevant downstream element in the neuroendocrine network governing LH secretion |
|
activates a receptor coupled to Galphaq subunits, KISS1R (activation of KISS1R signaling may negatively regulate the role of CXCR4 in programming tumor metastasis) |
|
strong suppressant of metastasis |
|
having a potential autocrine metastasis suppression effect on KISS1R-positive tumor cells |
|
being pivotal regulator of the hypothalamic-pituitary-gonadal axis and reproduction, with the ability to integrate signals from both internal and external sources |
|
functional kisspeptin is important for puberty and reproduction in humans |
|
is a key locus of integration for circadian and steroidal signaling necessary for the initiation of ovulation |
|
KISS1, KISS1R play a major role in trophoblast invasion, and progesterone-induced blocking factor (PIBF1) is needed for maintaining pregnancy |
|
may function in decidualized endometrium to prepare for adequate placentation but this autocrine secretion of KISS1 is deregulated during oncogenesis to enable tumor cells to spread |
|
KISS1/KISS1R signaling is critical for regulating the activity of gonadotropin-releasing hormone (GNRH1) neurons in mammals |
|
is a crucial activator of reproductive function |
|
is a 'master regulator' of reproductive physiology, integrating limbic circuits with the regulation of gonadotropin-releasing hormone neurons and reproductive hormone secretion |
|
plays an important role in regulating very early pregnancy events such as embryo implantation |
|
KISS1 is a metastasis suppressor gene of pancreatic cancer, and this suppression is not dependent on the expression levels of KISS1R |
|
CD82 and KISS1 are implicated in the pathogenesis and maintenance of endometriosis |
|
KISS1 has a role in male sexual behavior, which is specific to the medial amygdala (MePD) |
|
potential involvement of KISS1 protein in the pathogenesis and maintenance of adenomyosis |
|
regulates osteosarcoma apoptosis and autophagy processes |