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FLASH GENE
Symbol KIFC3 contributors: mct/npt - updated : 12-05-2020
HGNC name kinesin family member C3
HGNC id 6326
Location 16q21      Physical location : 57.792.130 - 57.836.439
Synonym name
  • kinesin-14
  • Synonym symbol(s) FKIF2, DKFZp686D23201, FLJ34694
    DNA
    TYPE functioning gene
    STRUCTURE 104.84 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D16S408 - D16S3334 - D16S3057 - KIFC3 - D16S3204 - D16S3089 - D16S400 - qter
    Authors Hoang (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3485 77 687 - 2019 31481795
    20 - 3359 92 826 - 2019 31481795
    20 - 3549 - 768 - 2019 31481795
    20 - 3505 - 848 - 2019 31481795
    18 - 3525 - 684 - 2019 31481795
    19 - 3330 92.64 833 - 2019 31481795
    21 - 3904 77 687 - 2019 31481795
    18 - 2982 - 724 - 2019 31481795
    19 - 3355 - 687 - 2019 31481795
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Endocrinethyroid    
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Epithelialsecretoryglandularendocrine 
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal globular domain
  • the motor domain with an ATP and the microtubule binding sites
  • a long alpa-helical coiled-coil region (stalk region), involved in dimerization
  • a small C-terminal motor domain, potentially involved in interaction with other proteins, vesicles or organelles
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Kifc3
    Homologene
    FAMILY
  • kinesin-like protein family, microtubule (MT) minus end-directed kinesin superfamily protein
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • in polarized epithelial cells, localized on membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells (Noda 2001)
  • CAMSAP2 anchors likely KIFC3 at microtubule minus ends and immobilizes microtubule arrays in dendrites
  • basic FUNCTION
  • playing a role in intracellular transport and mitosis
  • plays a complementary role in Golgi positioning and integration with cytoplasmic dynein (Xu 2002)
  • participate in polarized transport in epithelial cells as shown in the apical transport of ANXA13-containing vesicles (Hirokawa 2004)
  • functions as a regulatory or structural element of the adhesion protein complex rather than as a cargo motor (Meng 2008)
  • KIFC3 may play a regulatory role in minus-end directed peroxisomal transport for example by blocking the motor function of dynein at peroxisomes
  • may guide free microtubules to their destination at the bridge and/or may slide and crosslink central bridge microtubules in order to stage the cells for abscission
  • KIFC3, a minus-end-directed kinesin-14, provides microtubule-based centrosome cohesion
  • is important for organizing dendritic microtubules and to control dendrite development
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • RAB3IP, RAB10, and the microtubule minus-end-directed kinesin KIFC3 form a peroxisome-associated complex to control the movement of peroxisomes along microtubules, enabling communication between peroxisomes and ciliary pocket membranes
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • transported to cell junctions in a manner dependent on the PLEKHA7-NEZHA complex (Meng 2008)
  • cooperates with NEZHA for the maintenance of the zonula adherens (Meng 2008)
  • KIFC3 suppresses the ubiquitination and resultant degradation of CDH1 by recruiting USP47 to adherens junction (AJ), a process that may be involved in maintaining stable cell-cell adhesion in epithelial sheets
  • KIFC3 is eventually inactivated by NEK2 to enable KIF11-driven bipolar spindle assembly
  • KIFC3 has a dendrite-specific distribution and interacts with microtubule minus-end binding protein CAMSAP2
  • cell & other
  • micotubules
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in sporadic amyotrophic lateral sclerosis (SALS), and dependent of age
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS