Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PCK2 | contributors: mct - updated : 09-11-2014 |
HGNC name | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
HGNC id | 8725 |
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Corresponding disease |
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Location | 14q12 Physical location : 24.563.482 - 24.573.337 | ||
Synonym name | |||
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Synonym symbol(s) | PEPCK2, PEPCK.M, PEPCK, PEPCK-M | ||
EC.number | 4.1.1.32 |
DNA |
TYPE | functioning gene |
STRUCTURE | 9.86 kb 10 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter (CAAT box) |
cytosine-phosphate-guanine/HTF | |
text structure | several potential regulatory elements, including five GC boxes and three CCAAT boxes |
MAPPING | cloned | Y | linked | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to murine Pck2 |
homolog to C.elegans r11a5.4 |
Homologene |
FAMILY | phosphoenolpyruvate carboxykinase (GTP) family |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,mitochondria,matrix |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism | carbohydrate |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, nucleotide, |
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protein |
cell & other |
REGULATION |
activated by | ER stress triggers suppression of AMPK while increasing CEBPB and CREB1 expression which activates PCK2 gene transcription |
induced by | glucagon |
repressed by | insulin | |
ZNF692 (represses gene expression of PCK2, a key enzyme of gluconeogenesis |
Other | regulation of gene expression in the liver by KLF15 |
ASSOCIATED DISORDERS |
corresponding disease(s) | PCK2D |
related resource | MITOP database |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |