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FLASH GENE
Symbol SGTA contributors: mct - updated : 23-05-2013
HGNC name small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
HGNC id 10819
Location 19p13.3      Physical location : 2.754.711 - 2.783.354
Synonym name
  • small glutamine-rich tetratricopeptide repeat (TPR)-containing
  • Vpu-binding protein
  • protein containing three tetratricopeptide repeats
  • Synonym symbol(s) UBP, SGT
    DNA
    TYPE functioning gene
    STRUCTURE 28.64 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2358 34 313 - 1998 9740675
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal dimerisation domain (SGTA_NT)
  • a central tetratricopeptide repeat (TPR) domain,
  • small glutamine-rich protein containing three tetratricopeptide repeats
  • TPR domain is sufficient for the inhibition of HIV-1 particle release but the N- and/or C-terminus also have some contributions (
  • and a glutamine rich region towards the C-terminus
  • C-terminal region of SGTA plays a key role in binding a broad range of hydrophobic substrates, yet in contrast to the well-characterized N-terminal and TPR domains, there is a lack of structural information on the C-terminal domain
  • secondary structure
  • C-terminal domain region is characterized by alpha-helical propensity and an intrinsic ability to dimerize independently of the N-terminal domain
  • HOMOLOGY
    interspecies homolog to C.elegans R05F9.10
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • sub-cellular localization closely associated with Hsp90beta and apoptosis, because it is accumulated in the nucleus during cell apoptosis
  • basic FUNCTION
  • housekeeping function
  • probably functions as a molecular chaperone involved in protein folding and processing and may play a role in the regulation of myostatin secretion and activation (
  • essential for successful completion of cell division
  • essential for cell division since RNA-interference-mediated strong reduction of SGTA protein levels causes mitotic arrest
  • molecular rheostat of signaling competence by the AR
  • may play a role in androgen signaling as a co-chaperone
  • CDK5R1, HOPX, FKBP4, SGTA proteins plays a distinct role in the steroid hormone receptor regulatory cycle
  • BAG6/SGTA cycle operates likely during protein maturation and quality control in the cytosol and that together these components dictate the fate of a specific subset of newly synthesized proteins
  • SGTA recognizes a noncanonical ubiquitin-like domain in the BAG6-UBL4A-GET4 complex to promote endoplasmic reticulum-associated degradation
  • role for SGTA at distinct steps in the chaperone-dependent modulation of androgen, glucocorticoid, and progesterone receptor activity
  • SGTA overexpression was involved in the pathogenesis of breast cancer
  • SGTA regulates the cellular fate of a range of hydrophobic polypeptides should they become exposed to the cytosol
  • is an emerging player in the quality control of secretory and membrane proteins mislocalized to the cytosol, with established roles in tail-anchored (TA) membrane protein biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative member of the androgen receptor-chaperone-co-chaperone complex
  • SGTA-BAG6 complexes could be directly or indirectly required for complete chromosome congression
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NS1 protein of parvovirus H-1
  • 70kDa heat shock cognate protein
  • interacting with MSTN (N-terminal signal peptide of myostatin is essential for its association with SGTA and the C-terminal region of SGTA containing the third TPR motif was indispensable for its interaction with myostatin)
  • interacts with the hinge region of AR
  • interacted with not only Hsp90alpha but also Hsp90beta
  • can bind to both Vpu and Gag of human immunodeficiency virus type 1 (HIV-1) and the overexpression of SGT in cells reduces the efficiency of HIV-1 particle release
  • SGTA actively promotes the deubiquitination of mislocalized proteins that are already covalently modified, thus reversing the actions of BAG6 and inhibiting its capacity to promote substrate-specific degradation
  • SGTA can bind either BAG6, or UBL4A, but not both at the same time
  • binding of SGTA to ADRM1 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation
  • SGTA is a novel interacting partner of DKK3
  • SGTA overexpression regulates BST2 expression and stability, thus providing insights into the function of SGTA in ER translocation and protein degradation
  • implicated as a co-chaperone and regulator of androgen and growth hormone receptor (AR, GHR) signalling
  • direct interaction between SGTA and the proteasome, mediated by the intrinsic proteasomal ubiquitin receptor ADRM1 (27827410)
  • critical role of HSPA8 in SV40 ER-to-cytosol penetration and SGTA controls HSPA8 to impact this process
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal squamous cell carcinoma correlates with proliferation and poor prognosis
    Susceptibility to polycystic ovary syndrome (PCOS)
    Variant & Polymorphism SNP
  • haplotype 1 (G-A-T) associated with increased risk of PCOS and in women with PCOS, haplotype 2 (A-G-C) associated with increased insulin resistance
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    might serve as a future target for novel treatment in breast cancer
    ANIMAL & CELL MODELS
  • Sgta-null mutation in mice reports a mild phenotype of reduced body size