basic FUNCTION
| motor contractile protein moving towards the "plus" end of actin track |
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myosins IIA and IIB (MYH9 and MYH10), participate in neuronal adhesion, outgrowth and retraction ( |
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with MYH14 was found to be critical for driving neuronal process outgrowth |
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directly regulates cellular patterning and alignment within the cochlear sensory epithelium |
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possible role in maintaining the integrity of intercalated discs |
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potentially promotes TNF cell death signaling in a manner independent of its force generating property |
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possible role in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) |
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regulates actin dynamics during synaptic plasticity and memory formation |
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MYH9, MYH10, MYH14 are involved in regulating cardiac myocyte karyokinesis by affecting microtubule dynamics |
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MYH7B and MYH10 have distinct and overlapping effects on spine morphology |
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is involved in the enucleation of human erythroblasts |
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plays an essential and non-redundant role in cytokinesis during meiotic cell divisions of the male germline |
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acts as a regulator of multiple steps of cortical neuron migration and morphogenesis in the developing cortex |
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MYH9, MYH10, MYH14 are a group of molecular motors involved in a wide variety of cellular processes including cytokinesis, migration, and control of cell morphology |
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although MYH9 and MYH10 form filaments with similar properties, MYH14 forms filaments that are less well suited to roles such as tension maintenance within the cell |
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mediate centrosome reorientation during cell migration |
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is required for centriole migration to the apical plasma membrane, which occurs at the onset of ciliogenesis |
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is a key molecular factor that guides input-specific circuit maturation in the developing hippocampus |
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plays a major role in applying force on the nucleus to facilitate nuclear translocation through tight spaces 0) |
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MYH10 is essential for cardiac myocyte cytokinesis |
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required in epicardial formation and functions to support myocardial proliferation and coronary vessel development |
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regulates epicardial integrity and epicardium-derived mesenchymal cell maturation |
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role for MYH9 and MYH10 as negative regulators of proliferation in the mammary epithelium |
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requirement for MYH10 in epicardial function and coronary vessel formation, highlighting the importance of this protein in cardiac development and ultimately, embryonic survival |
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MYH9 plays a role in steering migration by maintaining stable protrusions in the anterior region, whereas MYH10 plays a role in maintenance of front-rear polarity by preventing aberrant protrusion formation in the posterior region |
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critical roles for MYH10 in alveologenesis at least in part via the regulation of ECM remodeling, which may contribute to the pathogenesis of emphysema |
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complementary functions of MYH9, MYH10 in the biogenesis and integrity of Adherens junction (AJ) |