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FLASH GENE
Symbol CDH16 contributors: mct - updated : 19-11-2013
HGNC name cadherin 16, KSP-cadherin
HGNC id 1755
Location 16q22.1      Physical location : 66.942.025 - 66.952.766
Synonym name
  • kidney-specific cadherin
  • Synonym symbol(s) PCADL1
    DNA
    TYPE like-sequence
    STRUCTURE 10.00 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • CDH16 minimal promoter is transcriptionally active in thyroid cells as well as in kidney cells
  • MAPPING cloned Y linked N status confirmed
    Map cen - D16S514 - D16S3019 - CDH16 - CDH1 - D16S496 - qter
    Authors Baudry (00)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid     Mus musculus
    Urinarykidney   specific SELECTED Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrinethyroid cell Mus musculus
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats with four cysteines in the most proximal (MPED)
  • a transmembrane segment
  • a highly conserved cytoplasmic tail required for interactions
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to CDH17
    Homologene
    FAMILY cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    basic FUNCTION
  • transmembrane glycoprotein component of adherens junction
  • cell-cell or cell-ECM interactions
  • playing a role in tumour suppression
  • functional cell-cell adhesion molecule related to CDH17
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component transmembrane glycoprotein constituent of adherens junction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hemophilic,calcium dependent interactions
  • interacting by its C terminus with the cytoskeleton via beta-catenin
  • is a novel downstream target of the transcription factor PAX8, likely since the early steps of thyroid development, and its expression is associated with the fully differentiated state of the thyroid cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS