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FLASH GENE
Symbol ANKRD17 contributors: mct/npt - updated : 22-06-2009
HGNC name ankyrin repeat domain 17
HGNC id 23575
Location 4q13.3      Physical location : 73.940.502 - 74.124.502
Synonym name
  • cDNA sequence,expressed in brain,86kDa
  • gene trap ankyrin repeat
  • serologically defined breast cancer antigen NY-BR-16
    • Synonym symbol(s) KIAA0697, GTAR, NY-BR-16
    DNA
    TYPE functioning gene
    STRUCTURE 184.00 kb     33 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    34 - 9390 274 2603 - Jones, Deng (2009)
    33 - 8637 260 2352 ubiquitous Jones, Deng (2009)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemuterus   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two clusters of a total 25 ankyrin repeats at its N terminus
  • one NES (nuclear exporting signal)
  • one NLS (nuclear localization signal) in the middle
  • one RXL motif at its C terminus
    • HOMOLOGY
    interspecies ortholog to murine Gtar
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text localized to the nucleus (Deng 2009)
    basic FUNCTION
  • may be directly involved in the DNA replication process
  • is an important downstream effector of cyclin E/CDK2 and positively regulates G1/S transition (Deng 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with DNA replication factors including MCM family members, CDC6 and PCNA (Deng 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS