basic FUNCTION
| involved in amino acid activation |
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peripheral protein that was tightly associated with the membrane via its N-terminal region |
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is primarily involved in membrane trafficking through early endosomes, but not through degradative organelles, such as multivesicular bodies and late endosomes |
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acting as a tRNA ligase |
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regulates the cellular levels of EGFR by contributing to the control of EGFR endosomal trafficking and degradation, regulating membrane trafficking through early endosomes |
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could have a general influence on the trafficking of receptors that are targeted via ubiquitination to the degradative pathway |
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regulates the dynamics of clathrin coats on early endosomes |
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DNAJ domain containing protein implicated in translocation of HSPA8 to early endosomes for clathrin removal during retrograde transport |
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is a co-chaperone on endosomes and may have a role in clathrin-coated vesicle endocytosis on this organelle |