basic FUNCTION
| required to recognize and demethylate trimethylated histone tails (converting specific trimethylated histone residues to the dimethylated form), a reaction important for gene regulation |
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mediating repression of E2F-regulated promoters |
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involved in cell proliferation and in oncogenesis |
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selectively repressing the expression of the ASCL2 gene |
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have a role of transcriptional repressor |
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reversed trimethylated H3-K9/K36 to di- but not mono- or unmethylated products |
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potentiating RB-mediated repression of E2F-regulated promoters and playing an important role in cell proliferation and oncogenesis |
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generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation |
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role for the JMJD2A/KDM4A H3K9/36 tridemethylase in cell cycle progression |
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regulates DNA replication by antagonizing CBX3 and controlling chromatin accessibility |
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H3K9-specific demethylating enzyme clearly required to facilitate the POU5F1-mediated derepression of the stem cell-related microRNAs |
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showed a degree of flexibility with regard to localization and demethylation frequency depending on the guide proteins to which it was fused |
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KDM4A, KDM4B, KDM4C, catalyze demethylation of tri- and di-methylated forms of both histone H3 lysine 9 (H3K9me3/me2) and lysine 36 (H3K36me3/me2) |