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FLASH GENE
Symbol AKAP11 contributors: mct - updated : 19-01-2013
HGNC name a kinase (PRKA) anchor protein 11
HGNC id 369
Location 13q14.11      Physical location : 42.846.288 - 42.897.402
Synonym name
  • A-kinase anchoring protein, 220kDa
  • protein kinase A anchoring protein
  • Synonym symbol(s) KIAA0629, AKAP220, FLJ11304, PRKA11
    DNA
    TYPE functioning gene
    STRUCTURE 51.11 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Map cen - D13S168 - AKAP11 - CPB2 - D13S153 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 9926 220 1901 - 2002 12147701
    - - 5947 - 1469 - 2002 12147701
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
     nerve   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure an amphipathic helix binding domain
    HOMOLOGY
    interspecies homolog to rattus A kinase anchoring protein AKAP220
    Homologene
    FAMILY AKAP110 family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    text cytoplasmic in premeiotic pachytene spermatocytes and
    in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating
    spermatocytes and mature sperm
    basic FUNCTION
  • a kinase (PRKA,regulating subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function
  • playing a role in regulating the Rb pathway, and its dysregulation may contribute significantly to alterations in cell cycle regulation
  • role for this anchored kinase/microtubule effector protein network in the propagation of cell motility
  • organizes IQGAP1 and GSK3B at the leading edge of motile cells in response to growth factors
  • participates in the integration and processing of calcium and cAMP signals that underlie directional mobilization of a microtubule-associated network at the leading edge of cells
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • formation of an IQGAP2-AKAP11 core complex initiates a subsequent phase of protein recruitment that includes the small GTPase Rac
  • AKAP11 serves as a platform for the assembly of a CLASP2-IQGAP sub-complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IQGAP2 and AKAP11 act synergistically to sustain PKA-mediated recruitment of effectors such as Rac GTPases that impact the actin cytoskeleton
  • AKAP11 interacts with the cytoskeletal scaffolding protein IQGAP1 to influence cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oral cancer
    tumoral        
    alters the rate of microtubule polymerization and the lateral tracking of growing microtubules and retards cell migration in metastatic human cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS