basic FUNCTION
| transfer RNA recognition by PRORP proteins is similar to that by ribonucleoprotein RNase P |
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TRMT10C along with HSD17B10 and KIAA0391, form the mitochondrial ribonuclease P (mt-RNase P) complex that cleaves the 5prime ends of mt-tRNAs from polycistronic precursor transcripts |
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is the nuclease component of the mtRNase P complex and requires a two-protein S-adenosyl-methionine (SAM)-dependent methyltransferase MRPP1/2 subcomplex to function |
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endonuclease PRORP is recruited and activated through interactions with its PPR and nuclease domains to ensure precise pre-tRNA cleavage |