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FLASH GENE
Symbol KIF3B contributors: mct/npt/pgu - updated : 28-09-2017
HGNC name kinesin family member 3B
HGNC id 6320
Corresponding disease
RP89 retinitis pigmentosa 89
Location 20q11.21      Physical location : 30.865.453 - 30.922.809
Synonym name
  • microtubule plus end-directed kinesin motor 3B
  • kinesin-like protein KIF3B
  • Synonym symbol(s) KIAA0359, HH0048, FLA8, KLP-11
    EC.number 3.6.4.4
    DNA
    TYPE like-sequence
    STRUCTURE 57.35 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 6135 85.1 747 - 1999 10548469
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Urinarykidney   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • globular N terminal domain
  • a central motor domain with an ATP binding site
  • a coiled-coil domain
  • a C terminal alpha helical tail, responsible for heterodimerization
  • HOMOLOGY
    interspecies homolog to murine kinesin KIF3B
    homolog to C.elegans y50d7a.6
    Homologene
    FAMILY
  • kinesin family 3
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text cilia
    basic FUNCTION
  • basic ciliary activity-putatively involved in the nodal flow supposed to break symetry
  • kinesin-2 complex (KIF3A, KIF3B) plays an important role not only in interphase but also in mitosis
  • PKP4 and ECT2 are transported via distinct motors, identifying a novel pathway implicating KIF3B in the regulation of actin organization during cytokinesis
  • heterotrimeric motor protein that facilitates fast anterograde translocation of membranous organelles
  • involved in the trafficking of SLC4A1 to the plasma membrane of kidney alpha-intercalated cells
  • playing a role in SLC4A1 trafficking to the plasma membrane
  • KIF3B mutant photoreceptor cilia differentiate with a delay, suggesting that KIF3C, although redundant with KIF3B at later stages of differentiation, is not active early in photoreceptor ciliogenesis
  • KIF3A, KIF3B (KIF3AB) is an N-terminal processive kinesin-2 family member best known for its role in intraflagellar transport
  • the kinesin-2 family motor KIF3A/KIF3B works together with dynein to bidirectionally transport intraflagellar particles, melanosomes, and neuronal vesicles
  • KIF3A, KIF3B, KIF3C is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text determination of left-right asymmetry, intracellular organelle transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • heterodimere of KIF3A and KIF3P
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CSPG6
  • associating with PKHD1 and PKD2 (mediates the regulation of PKD2 channel function by PKHD1)
  • interaction with ARHGEF10 (KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10)
  • CLCN5 interacts with kinesin family member 3B (C-terminus of CLCN5 and the coiled-coil and globular domains of KIF3B were shown to interact) (KIF3B)
  • SLC4A1 interacts with KIF3B in the kidney tissue (a dileucine motif at the C-terminal SLC4A1 contributes to its interaction with KIF3B)
  • RNF33 most likely interacted with KIF3A-KIF3B independent of the adaptor kinesin-associated protein KIFAP3
  • GLI1 interactions with KIF3A-KIF3B-KIFAP3 complexes are essential for proper GLI1 transcriptional activity
  • PKP4 directly interacts with the KIF3/subunit KIF3B, and also interacts with the kinesin cargo adaptor protein KIFAP3 acting as a stabilizing linker between KIF3B and its KIFAP3 cargo binding entity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP89
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC)tumor tissues and proliferating HCC cells, and an increased KIF3B expression was associated with poor overall survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    murine Kif3b-/- have randomized situs