basic FUNCTION
| GTPase activating protein for the ras-related p21rac |
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DAG (diacylglycerol) receptor |
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playing a role in T-cell receptor signaling |
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negatively controls many Rac-dependent pathophysiological events including tumor development |
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provides a novel, diacylglycerol-dependent mechanism for Rac regulation in T cells, playing a functional role in Rac-mediated cytoskeletal remodeling |
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GTPase-activating proteins that inactivate the GTP-hydrolase RAC1 in a diacylglycerol-dependent manner |
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inactivating Rac1 in response to EPHA1 stimulation (Takeuchi 2009) |
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mediates the EphA receptor-dependent regulation of cell migration (Takeuchi 2009) |
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a key element of proximal insulin signaling |
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is required for SEMA3F-dependent presynaptic pruning but it is not essential for SEMA3F-mediated hippocampal dentate gyrus (DG) axon repulsion |
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important regulator of the small GTPase Rac |
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plays an important role in adipogenesis and chemotaxis of the innate immune system |