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FLASH GENE
Symbol MOCS1 contributors: mct - updated : 15-05-2013
HGNC name molybdenum cofactor synthesis 1
HGNC id 7190
Corresponding disease
MOCODA molybdenum cofactor deficiency, type A
Location 6p21.2      Physical location : 39.872.034 - 39.902.290
Synonym name
  • migration-inducing gene 11 protein
  • molybdenum cofactor synthesis-step 1 protein A-B
  • MOCS1A enzyme
  • Synonym symbol(s) MOCOD, MIG11, MOCS1A, MOCS1B, KIAA0381
    EC.number 4.1.99.18
    DNA
    TYPE functioning gene
    STRUCTURE 30.21 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure two open reading frames separated from each other by a stop codon and a Kozack consensus sequence,encoding E Coli moaA (MOCS1A) and moaC (MOCS1B) homolog,independently translated
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 4159 - 385 - Reiss (2003)
    bicistronic transcript ex 1b, 1c, 1d
    10 splicing 4163 - 385 - Reiss (2003)
    ex 1a,1d
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Reproductivefemale systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved C terminal isoleucine-glycine-glycine-stop motif
  • moaC (MOCS1B) homolog, independently translated
    HOMOLOGY
    Homologene
    FAMILY
  • moaC family
  • moaA/nifB/pqqE family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • bicistronic nuclear gene involved in molybdenum cofactor synthesis, step 1, leading to precursor Z
  • catalyzing the conversion of a guanosine derivative to precursor Z during molybdenum cofactor biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MOCODA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS